To Evaluate the Functional Outcome of Platelet Rich Plasma Therapy in Osteoarthritis of Knee
Background: Osteoarthritis of knee is a chronic, degenerative condition associated with pain, deformity, disability, difficulty in movements and reduction in the quality of life. This study aims to assess the efficacy of intra-articular injection of autologous platelet rich plasma (PRP) therapy in the management of osteoarthritis of knee.
Material and methods: 50 patients with symptomatic knee osteoarthritis were treated by 5 ml autologous intra-articular PRP injection and were assessed for pain, quality of life and rate of satisfaction by WOMAC score.
Results: 50 cases (KL grade II 18 and grade III 22) were included in the study. In KL grade II, the mean WOMAC score, pretreatment was 57.11 ± 6.36, which improved to 53.76 + 7.6 (p=0.000) at 2 weeks, to 31.97 ± 4.51 (p=0.001) at one month, to 26.97 ± 3.47(p=0.001) at 3 months and to 22.11 ± 2.99 (p=0.001) at final follow-up of 6 months. In KL grade III, the mean WOMAC score pretreatment was 59.21 ± 5.63, which improved to 55.76 ± 7.6 (p=0.000) at 2 weeks, to 48.79 ± 5.42 (p=0.001) at one month, to 36.46 ± 4.36 (p=0.001) at 3 months, and to 32.12 ± 2.66 (p=0.001) at final follow-up of 6 months.
Conclusion: Use of single PRP intra-articular injection in the management of osteoarthritis knee provides excellent pain relief, improvement in quality of life and high rate of satisfaction, which is more effective in the early stages of osteoarthritis than the advanced stage. Relief starts immediately and it increases gradually with time. PRP is a safe, easy, minimally invasive and cheap alternative in the management of knee osteoarthritis.
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