Study of PRP assisted wound repair and regeneration in chronic non healing wounds
Abstract
Background: Chronic non healing wounds are a cause of severe pain and disability in a large number of patients. Usually these patients are suffering from conditions which has lowered their capacity to heal the wound because of variety of systemic, metabolic or local disturbances in milieu interior. Some of the commonest types of these non-healing wounds are vascular ulcers, diabetic ulcers and pressure ulcers. The usual strategy to treat these ulcers like TIME strategy is not always sufficient and some wounds remain unresponsive to current therapies. Platelet rich plasma (PRP) is a rich source of complex group of growth factors essential for natural wound repair. PRP therapy was used in current study to assess its role in healing of chronic wounds.
Methods: The present study was carried out in 35 patients of various age and sex groups. All these patients had chronic non healing wounds which had not responded to conventional therapy. Wound size was measured at the initiation of protocol by graph method. PRP was prepared using standard two spin technique. The PRP so prepared was injected in the periphery of the wound as per STARS protocol every fourth day. Saline dressings were done regularly and no antiseptics or antibiotics were used. No analgesics were given. Wound size was determined at every fourth day at the time of injection using graph method.
Results: Out of 35 wounds, 30 wounds healed completely within 40 days of starting therapy. In none of the cases antibiotics or wound debridement was required. Of the remaining 05 wounds there was a significant reduction in size, pain and infection.
Conclusion: PRP injection for treatment of chronic non-healing wounds is an effective method of treatment irrespective of their etiology
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References
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