Future orthopaedics: role of stem cells

  • Maravi D S Assossiate Professor, Department of Orthopaedics, Gandhi Medical College & Hamidia Hospital, Bhopal, India
  • Singh V Resident Surgical Officer, Gandhi Medical College & Hamidia Hospital, Bhopal, India
  • Shukla J. Professor, Department of Orthopaedics, Gandhi Medical College & Hamidia Hospital, Bhopal, India
  • Gaur S. Professor & Head, Department of Orthopaedics, Gandhi Medical College & Hamidia Hospital, Bhopal, India
Keywords: Future orthopaedics, foetal stem cells (FSCs), embryonic stem cells (ESCs)

Abstract

Today great hope is set on regenerative medicine in all medical fields. Leland Kaiser introduced the term "Regenerative medicine" in 1992. He forecasted that "a new branch of medicine will develop that attempts to change the course of chronic diseases and in many instances will regenerate tired and failing organ systems"1 Since then, scientists all over the world try to develop cell-based approaches to regenerate damaged tissues, or even substitute whole organs2. Of course, regenerative medicine has developed to be of interest in orthopaedics. There, great hope was set on regenerative medicine to develop alternative therapies for cartilage damage, arthritis, large bone defects, or atrophic tendon ruptures during the last decade. These are all indications, which are treatable only insufficiently with conventional implants and surgical procedures3-10. Therefore, they frequently result in decreased function of the musculoskeletal system or even loss of patients' mobility. In the worst case, the mentioned diseases even result in a loss of autonomy for the patient. In the field of Orthopaedics, autologous stem cells such as mesenchymal stem cells (MSCs) are readily available and are amenable to harvesting and isolation from the bone marrow and other tissues of mesodermal origin. MSCs are already pre-programmed to differentiate into musculoskeletal tissue types. But Despite rapid progress, significant challenges remain in the translation of these stem cell therapies for clinical applications. In this review, a brief description of stem cells is provided, and the current status of stem cells in orthopaedic practice is discussed.

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Published
2015-06-30
How to Cite
1.
Maravi D S, Singh V, Shukla J., Gaur S. Future orthopaedics: role of stem cells. ojmpc [Internet]. 2015Jun.30 [cited 2024Mar.29];21(1):15-3. Available from: https://ojmpc.com/index.php/ojmpc/article/view/5
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Review Article