Evaluation of role of antibiotic cement impregnated intramedullary nail in infected long bone fractures
Abstract
Infected long bone fracture is a debilitating disorder. Traditionally treatment of infected long bone fracture follows the multistage procedure such as debridement and systemic antibiotics with temporary fixation and than permanent fixation and bone grafting when required or bone transport.For the treatment of infected long bone fracture Single staged procedures such as debridement and application of Ilizarov fixator and limb reconstruction system (LRS) are also available but these procedures are technically demanding, need good patients compliance and regular long term follow up.This study was to evaluate the role of antibiotic cement impregnated intramedullary nail (ACIIN) in treatment ofinfected long bone fractures. ACIINs provide a high concentration of antibiotics locally, provide mechanical stability, good infection control, promotes bone union by simple and one stage procedure. We prospectively studied a cohort of 25 culture positive cases with infected long bone fracture with bone defect less then 2 cm (22 tibia and 3 femur), mean age being 35.4 year were treated by ACIINs. Most common organism isolated in culture was staphylococus aureus. Infection control was judged on the basis of discharge through the wound and laboratory parameters at regular follow up. 24 cases achieved infection control and bone union without need of other secondary procedure and only one patient shows poor result that lost to follow up. So we find ACIINs as single stage procedure for controlling infection, providing mechanical stability and there by promoting bone union in infected long bone fracture.
Downloads
References
Court-Brown CM. Fractures of the tibia and fibula. In: Bucholz RW, Heckman JD, Court-Brown CM, editors. Rockwood and Green's fractures in adults. 6th ed. Lippincott Williams and Wilkins; 2006. p. 2080-146.
Ueng SW, Chuang DC, Cheng SL, Shih CH. Management of large infected tibial defects with radical debridement and staged double-rib composite free transfer. J Trauma 1996;40:345-9.
McKee MD, Yoo DJ, Zdero R, Dupere M, Wild L, Schemitsch EH, et al. Combined single-stage osseous and soft tissue reconstruction of the tibia with the Ilizarov method and tissue transfer. J Orthop Trauma 2008;22:183-9.
Qiang Z, Jun PZ, Jie XJ, Hang L, Bing LJ, Cai LF . Use of antibiotic cement rod to treat intramedullary infection after nailing: Preliminary study in 19 patients. Arch Orthop Trauma Surg 2007;127:945-51.
Thonse R, Conway J. Antibiotic cement-coated interlocking nail for the treatment of infected nonunions and segmental bone defects. J Orthop Trauma 2007;21:258-68
Rajesh dhanasekhar et al. Antibiotic cement impregnated nailing in management of infected non union of femur and tibia :Kerala J Orthop 2013; 26:93-97.
Zalavras CG, Patzakis MJ, Holtom P. Local antibiotic therapy in the treatment of open fractures and osteomyelitis. Clin Orthop Relat Res. 2004;427: 8693.
Henry SL, Ostermann PA, Seligson D. The prophylactic use of antibiotic impregnated beads in open fractures. J Trauma. 1990;30:1231-8.
Ashok K. Shyam, Parag K Sancheti et al.: use of antibiotic cement impregnated intramedullary nail in treatment of infected non-union of long bones. Indian j orthop. 2009 oct.;43 (4) :396-402
Koo KH, Yang JW, Cho SH, Song HR, Park HB, Ha YC, et al. Impregnation of vancomycin, gentamicin, and cefotaxime in a cement spacer for two-stage cementless reconstruction in infected total hip arthroplasty. J Arthroplasty 2001;16:882-92.
Lindsey RW, Probe R, Miclau T, Alexander JW, Perren SM. The effects of antibiotic-impregnated autogeneic cancellous bone graft on bone healing. Clin Orthop Relat Res. 1993;291:303-12.
Gallo J, Kolár M, Florschütz AV, Novotný R, Pantucek R, Kesselová M. In vitro testing of gentamicinvancomycin loaded bone cement to prevent prosthetic joint infection. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005;149:153-8.
Patzakis MJ, Wilkins J, Wiss DA. Infection following intramedullary nailing of long bones: diagnosis and management. Clin Orthop Relat Res 1986;212:18291.
B. W. Kooistra, B. G. Dijkman, J. W. Busse: "The radiographic union scale in tibia fracture: reliability and validity". J of ortho. Trauma, vol.24, supl.1, pp. s81- s86. 2010.
S. Morshed, L. Corrales et al.: "outcome assessment in clinical trial of fracture- healing". Jbjs am. Vol.90. supl.1. pp.62-67. 2008
The entire contents of the Orthopaedic Journal of Madhya Pradesh Chapter are protected under Indian and International copyrights. Orthopaedic Journal of Madhya Pradesh Chapter allow authors to retain the copyrights of their papers without restrictions, Authors grant the publisher the right of exclusive publication. The Journal then grants to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, perform and display the work publicly and to make and distribute derivative works in any digital medium for any reasonable non-commercial purpose, subject to proper attribution of authorship. The journal also grants the right to make numbers of printed copies for their personal non-commercial use under Creative Commons Attribution-Non-commercial share alike 4.0 International Public License.